The Giallorossi have suffered a mixed campaign so far and a 1-0 defeat to Juventus last time out leaves them coming into the new year in seventh place in the Serie A table.
Atalanta are a point and a position ahead of Roma and will be hoping for victory in the capital to boost their own Champions League qualification ambitions.
AS Roma vs Atalanta: Predicted line-ups
As reported by La Gazzetta dello Sport, Roma are still waiting on the return to fitness of Tammy Abraham, Marash Kumbulla, and Chris Smalling, but coach Jose Mourinho has an otherwise fully-fit squad.
Forwards Romelu Lukaku and Paulo Dybala are expected to lead the line, whilst former Atalanta pair Gianluca Mancini and Bryan Cristante will feature.
La Dea are without El Bilal Toure through injury, whilst defenders Rafael Toloi and Jose Luis Palomino, as well as wing-back Hans Hateboer, face late fitness tests.
Roma centre-back Mancini is one booking away from suspension.
AS Roma predicted XI vs Atalanta (3-5-2): Rui Patricio; Mancini, Llorente, Ndicka; Kristensen, Cristante, Paredes, Bove, Zalewski; Dybala, Lukaku.
Atalanta predicted XI vs AS Roma (3-4-1-2): Carnesecchi; Scalvini, Djimsiti, Kolasinac; Zappacosta, De Roon, Ederson, Ruggeri; Koopmeiners; Lookman, De Ketelaere.
Serie A: When does AS Roma vs Atalanta start?
Kick-off in the Serie A Matchday 19 fixture of AS Roma vs Atalanta is set for 20:45 CET, local time in Italy, on Sunday, January 7.
For viewers in the United Kingdom and Ireland, the game will start at 19:45 GMT. That is 14:45 ET / 11:45 PT in the United States.
Serie A: Where to watch AS Roma vs Atalanta?
For fans in the United States, AS Roma vs Atalanta will be on Paramount+ along with other fixtures on Serie A Matchday 19.
AS Roma vs Atalanta will be shown on TNT Sports 1 in the United Kingdom and Ireland.