The Giallorossi moved into the top four with a come-from-behind 2-1 win against Sassuolo and are unbeaten in four league matches, as they target a return to the Champions League.
However, they are coming up against a Fiorentina side who are breathing down their necks and are just a single point behind Roma in the Serie A table.
AS Roma v Fiorentina: Predicted line-ups
As reported by La Gazzetta dello Sport, Roma are without Tammy Abraham and Marash Kumbulla are still long-term absentees, whilst Chris Smalling is not expected to play a part in the match.
Jose Mourinho has the rest of his squad available to him, and is likely to continue with Paulo Dybala and Romelu Lukaku up front.
Fiorentina coach Vincenzo Italiano is without long-term injured pair Dodo and Gaetano Castrovilli, and is likely to turn to Nicolas Gonzalez and Riccardo Sottil either side of striker M’Bala Nzola.
Roma centre-back Gianluca Mancini is one booking away from suspension, whilst Fiorentina midfielder Giacomo Bonaventura will also face a ban should he pick up a yellow card in the match.
AS Roma predicted XI vs Fiorentina (3-5-2): Rui Patricio; Mancini, Llorente, Ndicka; Karsdorp, Cristante, Paredes, Bove, Spinazzola; Dybala, Lukaku
Fiorentina predicted XI vs AS Roma (3-5-2): Terracciano; Kayode, Milenkovic, Ranieri, Biraghi; Arthur Melo, Duncan; Gonzalez, Bonaventura, Sottil; Nzola.
Serie A: When does AS Roma vs Fiorentina start?
Kick-off in the Serie A Matchday 15 fixture of AS Roma vs Fiorentina is set for 20:45 CET, local time in Italy, on Sunday, December 10.
For viewers in the United Kingdom and Ireland, the game will start at 19:45 GMT. That is 14:45 ET / 11:45 PT in the United States.
Serie A: Where to watch AS Roma vs Fiorentina?
For fans in the United States, AS Roma vs Fiorentina will be on Paramount+ along with other fixtures on Serie A Matchday 15.
AS Roma vs Fiorentina will be shown on TNT Sports 2 in the United Kingdom and Ireland.