The Giallorossi have endured a dreadful start and come into the match off the back of a 4-1 drubbing at the hands of Genoa in Matchday 6.
Frosinone, on the other hand, will be happy with their opening results after securing two wins and three draws from their first six matches.
AS Roma vs Frosinone: Predicted line-ups
As reported by La Gazzetta dello Sport, Roma are short of defensive options following injuries to Diego Llorente and Chris Smalling, so Bryan Cristante is expected to drop back.
Paulo Dybala and Romelu Lukaku will continue upfront, whilst Houssem Aouar is expected to join Lorenzo Pellegrini and Leandro Paredes in midfield.
The Lupi are without the injured Tammy Abraham, Marash Kumbulla and Renato Sanches.
Frosinone look to Walid Cheddira to lead the line, with the Moroccan flanked by Jaime Baez and Matias Soule.
AS Roma predicted XI vs Frosinone (3-5-2): Rui Patricio; Mancini, Cristante, Ndicka; Kristensen, Aouar, Paredes, Pellegrini, Spinazzola; Dybala, Lukaku
Frosinone predicted XI vs AS Roma (4-3-3): Turati; Oyono, Okoli, Romagnoli, Marchizza; Mazzitelli, Barrenechea, Garritano; Soule, Cheddira, Baez
AS Roma vs Frosinone: When does the Serie A fixture start?
Kick-off in the Serie A Matchday 7 fixture of AS Roma vs Frosinone is set for 20:45 CEST, local time in Italy, on Sunday, October 1.
For viewers in the United Kingdom and Ireland, the game will start at 19:45 BST. That is 14:45 EST / 11:45 PST in the United States.
AS Roma vs Frosinone: Where to watch the Serie A fixture?
For fans in the United States, AS Roma vs Frosinone will be on Paramount+ along with other fixtures on Serie A Matchday 7.
AS Roma vs Frosinone will be shown on TNT Sports 1 in the United Kingdom and Ireland.