The Giallorossi secured a 1-0 win over Torino last time out to move into third place and bolster their push for a Champions League qualification spot, but cannot allow for complacency against the Zebrette.
In the first meeting between the pair, Udinese inflicted a first defeat of the campaign on Roma with a stunning 4-0 result, and they will be looking to cement a top half finish with another win.
AS Roma vs Udinese: Predicted line-ups
As per La Gazzetta dello Sport, Roma are expected to recall defender Roger Ibanez in place of Diego Llorente, whilst Andrea Belotti could be handed a rare start after Ola Solbakken picked up an injury against Torino.
Rick Karsdorp remains out with injury, whilst Ebrima Darboe is still not fit enough to return after suffering a long-term injury in preseason.
Udinese, meanwhile, are without forward Gerard Deulofeu through injury, so Isaac Success and Beto will lead the line.
Roma midfielder Nemanja Matic is one booking away from suspension, whilst Udinese pair Sandi Lovric and Destiny Udogie will also receive a ban with a yellow card.
AS Roma predicted XI vs Udinese (3-4-2-1): Rui Patricio; Mancini, Smalling, Ibanez; Zalewski, Matic, Cristante, Spinazzola; Dybala, Wijnaldum; Belotti
Udinese predicted XI vs AS Roma (3-5-2): Silvestri; Becao, Bijol, Perez; Ehizibue, Lovric, Walace, Pereyra, Udogie; Success, Beto
AS Roma vs Udinese: When does the Serie A fixture start?
Kick-off in the Serie A Matchday 30 fixture of AS Roma vs Udinese is set for 20:45 CEST, local time in Italy, on Sunday, April 16.
For viewers in the United Kingdom and Ireland, the game will start at 19:45 BST. That is 14:45 EDT / 11:45 PDT in the United States.
AS Roma vs Udinese: Where to watch the Serie A fixture?
For fans in the United States, AS Roma vs Udinese will be on Paramount+ along with other fixtures on Serie A Matchday 30.
AS Roma vs Udinese will be shown on BT Sport 1 in the United Kingdom and Ireland.