The Giallorossi sit in fourth place but are only one spot ahead of their opponents and are level on 25 points, having earned a 1-1 draw against Fiorentina last time out despite finishing the match with nine men.
Bologna, meanwhile, have been in superb form and have only suffered a single defeat since August, as they challenge for a European qualification spot.
Bologna vs AS Roma: Predicted line-ups
As reported by La Gazzetta dello Sport, Roma are still waiting on the return to fitness of Tammy Abraham, Marash Kumbulla, and Chris Smalling, whilst Paulo Dybala and Sardar Azmoun miss out after sustaining injuries against Fiorentina.
Gianluca Mancini should recover from a knock in time to take his place in the starting line-up, whilst Andrea Belotti is expected to replace the suspended Romelu Lukaku in attack, after his red card against the Viola. Nicola Zalewski also serves a suspension after being dismissed in that draw.
Bologna are in the midst of an injury crisis, with Riccardo Orsolini, Lorenzo De Silvestri, and Kevin Bonifazi all ruled out, joining Adama Soumaoro, Jesper Karlsson, Tommaso Corazza and Oussama El Azzouzi in the treatment room.
Roma centre-back Mancini is one booking away from suspension, whilst Bologna’s Michel Aebischer will also face a ban should he pick up a yellow card in the match.
Bologna predicted XI vs AS Roma (4-2-3-1): Skorupski; Posch, Lucumi, Calafiori, Lykogiannis; Aebischer, Freuler; Ndoye, Ferguson, Saelemaekers; Zirkzee.
AS Roma predicted XI vs Bologna (3-5-2): Rui Patricio; Mancini, Llorente, Ndicka; Karsdorp, Cristante, Paredes, Pellegrini, Spinazzola; Belotti, El Shaarawy.
Serie A: When does Bologna vs AS Roma start?
Kick-off in the Serie A Matchday 16 fixture of Bologna vs AS Roma is set for 18:00 CET, local time in Italy, on Sunday, December 17.
For viewers in the United Kingdom and Ireland, the game will start at 17:00 GMT. That is 12:00 ET / 09:00 PT in the United States.
Serie A: Where to watch Bologna vs AS Roma?
For fans in the United States, Bologna vs AS Roma will be on Paramount+ along with other fixtures on Serie A Matchday 16.
Bologna vs AS Roma will be shown on TNT Sports 2 in the United Kingdom and Ireland.