Having made it all the way to the final of the Europa Conference League last season, only to lose late on against West Ham United, Fiorentina will begin the journey again with a trip to face Genk.
The other two teams in this Conference League group are Hungarian giants Ferencvaros and Serbian side Cukaricki. It could be quite a tight group with multiple teams having a handful of very talented players.
Fiorentina enjoyed a victory over Atalanta at the weekend to prepare for this game, whilst Genk are stuttering in the Belgian Pro League with 11 points from six games so far, sitting sixth in the table.
Genk vs Fiorentina: Predicted lineups
Things are currently looking pretty good for Genk from a fitness perspective. The only player that they are expected to be without against Fiorentina is goalkeeper Vic Chambaere who has got a back injury.
There are a few more injuries at Fiorentina for Vincenzo Italiano to work around, as La Viola will be without Yerry Mina, Jonathan Ikone, Gaetano Castrovilli and Niccolo Pierozzi thanks to various injuries.
Genk predicted lineup vs Fiorentina (4-2-3-1): Vandevoordt; Munoz, Cuesta, Sadick, Kayembe; El Khannouss, Galarza; Heynen, Zeqiri, Oyen; Paintsil
Fiorentina predicted lineup vs Genk (4-3-3): Terracciano; Dodo, Milenkovic, Martinez-Quarta, Biraghi; Duncan, Arthur; Gonzalez, Bonaventura, Brekalo; Beltran
Genk vs Fiorentina: When does the Europa Conference League fixture start?
Kick-off in the Europa Conference League Matchday 1 fixture of Genk vs Fiorentina is set for 18:45 CEST, local time in Belgium, on Thursday, September 20.
For viewers in the United Kingdom and Ireland, the game will start at 17:45 BST. That is 12:45 EDT / 09:45 PDT in the United States.
Genk vs Fiorentina: Where to watch the Europa Conference League fixture?
For fans in the United States, Genk vs Fiorentina will be on Paramount+ along with other fixtures on Europa Conference League Matchday 1.
Genk vs Fiorentina will be shown on TNT Sports 8 in the United Kingdom and Ireland.