The Giallorossi were denied a first away win of the season by a late Torino equaliser in a 1-1 draw on Sunday, leaving them with just a single victory so far this campaign.
Genoa are only a single point behind Roma after a win and a draw from their opening five matches, and the newly promoted Grifone will be looking for another scalp after beating Lazio in August.
Genoa vs AS Roma: Predicted line-ups
As reported by La Gazzetta dello Sport, Roma are expected to continue the burgeoning partnership of Romelu Lukaku and Paulo Dybala in attack, and Houssem Aouar could make his return from injury in midfield.
Tammy Abraham and Marash Kumbulla are still several months away from a return, whilst midfielder Renato Sanches is also ruled out through injury.
Genoa look to Italy Men’s National Team striker Mateo Retegui for goals, with the Argentine-born attacker paired with Albert Gudmundsson. Former Roma favourite Kevin Strootman is expected to start in midfield for the Grifone.
Coach Alberto Gilardino will be without injured duo Junior Messias and Alessandro Vogliacco, whilst Aaron Martin serves a suspension.
Genoa predicted XI vs AS Roma (3-5-2): Martinez; De Winter, Bani, Dragusin, Vasquez; Sabelli, Strootman, Badelj, Frendrup; Gudmundsson, Retegui
AS Roma predicted XI vs Genoa (3-5-2): Rui Patricio; Mancini, Ndicka, Llorente; Kristensen, Aouar, Paredes, Cristante, Spinazzola; Dybala, Lukaku
Genoa vs AS Roma: When does the Serie A fixture start?
Kick-off in the Serie A Matchday 6 fixture of Genoa vs AS Roma is set for 20:45 CEST, local time in Italy, on Thursday, September 28.
For viewers in the United Kingdom and Ireland, the game will start at 19:45 BST. That is 14:45 EST / 11:45 PST in the United States.
Genoa vs AS Roma: Where to watch the Serie A fixture?
For fans in the United States, Genoa vs AS Roma will be on Paramount+ along with other fixtures on Serie A Matchday 6.
Genoa vs AS Roma will be shown on TNT Sports 1 in the United Kingdom and Ireland.