Neither side are having the season that they expected so far and defeat for either will be met with serious anger from the fanbases, perhaps more so for Milan who are without a win since January 4.
Both sides appear too far away from Napoli now to be thinking about a title challenge, meaning cementing a place in the top four is the order of the next few months. Inter are the home side for this one, meaning they will have the majority inside the Stadio Giuseppe Meazza.
Inter vs AC Milan: Predicted lineups
Milan are expected to be without Ismael Bennacer for the derby and they could also be missing Fikayo Tomori as well. That means Tommaso Pobega and Simon Kjaer could come in.
As for the Nerazzurri, they will get Milan Skirniar and Nicolo Barella back from suspension, whilst Marcelo Brozovic should be back in the squad. Inter do have a Coppa Italia tie against Atalanta to contend with on Tuesday which could bring injuries.
Inter predicted XI vs AC Milan (3-5-2): Onana; Skriniar, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro, Dzeko.
AC Milan predicted XI vs Inter (4-2-3-1): Tatarusanu; Calabria, Kjaer, Kalulu, Hernandez; Pobega, Tonali; Saelemaekers, Diaz, Leao; Giroud.
Inter vs AC Milan: When does the Serie A fixture start?
Kick-off in the Serie A Matchday 21 fixture of Inter vs AC Milan is set for 20:45 CET, local time in Italy, on Sunday, February 5.
For viewers in the United Kingdom and Ireland, the game will start at 19:45 GMT. That is 14:45 ET / 11:45 PT in the United States.
Inter vs AC Milan: Where to watch the Serie A fixture?
For fans in the United States, Inter vs AC Milan will be on Paramount+ along with other standout fixtures in Serie A Matchday 21.
Inter vs AC Milan will be shown on BT Sport 1 in the United Kingdom and Ireland.