The Giallorossi are looking to maintain their push for Champions League qualification after a gruelling week, in which they secured their place in the knockout stages of the Europa League and faced city rivals Lazio.
Sassuolo, meanwhile are sitting comfortably in midtable and facing Empoli on Saturday, ahead of their test against Jose Mourinho‘s Lupi.
Sassuolo v AS Roma: Predicted line-ups
Roma are still without injured summer signings Paulo Dybala and Georginio Wijnaldum, whilst wing-back Leonardo Spinazzola is in doubt as he works his way back from a thigh injury.
Sassuolo coach Alessio Dionisi is unable to call upon former Roma forward Gregoire Defrel through injury, whilst fellow attacker Domenico Berardi is a doubt for the match.
The Neroverdi are also without full-back Mert Muldur, although he is closing in on a return from an ankle fracture sustained in August.
Sassuolo XI to face AS Roma (4-3-3): Consigli; Toljan, Erlic, Ferrari, Rogerio; Frattesi, Lopez, Thorstvedt; Konradsen Ceide, Pinamonti, Lauriente
AS Roma XI to face Sassuolo (3-5-2): Rui Patricio; Mancini, Smalling, Ibanez; Zeki Celik, Cristante, Pellegrini, Camara, Zalewski; Zaniolo, Belotti
Sassuolo v AS Roma: When does the Serie A fixture start?
Kick-off in the Serie A Matchday 14 fixture of Sassuolo v AS Roma is set for 18:30 CET, which is local time in Italy, on Wednesday, November 9. For viewers in the United Kingdom and Ireland, the game will start at 17:30 GMT. That is 12:30 ET / 10:30 PT in the United States.
Sassuolo v AS Roma: Where to watch the Serie A fixture?
Sassuolo v AS Roma in Serie A will be shown on BT Sport 1 in the United Kingdom and Ireland on Wednesday, November 9.
For fans in the United States, Sassuolo v AS Roma will be on Paramount+ along with other key fixtures in Serie A Matchday 14.