The Biancocelesti were level with the Nerazzurri until the Spaniard entered the match on Friday night, but left the Stadio Olimpico in Rome with a 3-1 Serie A win.
It was the first time since October 2021 that Simone Inzaghi’s team had conceded three goals in a match, when losing by the same scoreline against the Aquile in the capital last term.
Felipe Anderson had given the capital club the lead on 40 minutes, but Lautaro Martinez equalised for the visitors just after half-time, which prompted the introduction of the ex-Liverpool midfielder and countryman Pedro a few minutes later.
On 75 minutes, the former Chelsea winger would roll the ball along the edge of the Inter box for Alberto, who sent a thunderous drive past goalkeeper Samir Handanovic and into the top corner.
Pedro added the third goal 11 minutes later, as the Spanish duo became the first and second players to score a substitute league goal in a match between the two sides since 8 May 2013.