An assist and a goal from the Argentina international helped the Giallorossi rise to fifth in the standings, three points behind reigning champions Napoli and within touching distance of a Champions League qualification place.
Udinese getting sick of seeing Paulo Dybala
The 30-year-old has now been directly involved in 19 goals against the Zebrette and only Roma legend Francesco Totti has a better Serie A record against one club, with 20 goal involvements versus Parma.
Despite defending deep and an aggressive approach to stopping Dybala, Udinese could not hold out for long, and the Giallorossi attacker curled over an inch perfect free kick on 19 minutes for Gianluca Mancini to head home.
Crucial goal from Paulo Dybala secures Serie A milestone for Roma
With time running out and the Giallorossi staring at two dropped points, it was Dybala who collected the ball on the edge of the box, exchanged passes with Romelu Lukaku and burst forward to finish cooly past Marco Silvestri.
Although Stephan El Shaarawy added a late third, the ex-Juventus man’s strike was crucial to sealing the win, but also had added importance for the Romans, as it was their 4500th in Serie A action. Only The Old Lady (5322), Inter (5246) and AC Milan (4966) have scored more in the top flight.