The Giallorossi were a penalty shootout away from lifting the trophy against Sevilla in May and are looking to go one better this season, as they seek to build on a 7-0 thrashing of Empoli in Serie A last time out.
Sheriff welcome the Italian club to Tiraspol and will be hoping to claim a scalp ahead of fixtures against Slavia Praha and Servette in Group G.
Sheriff vs AS Roma: Predicted line-ups
As reported by Sportface.it, Roma are unable to call upon either Rasmus Kristensen or Sardar Azmoun due to neither being included in their Europa League squad, whilst Chris Smalling is unlikely to be risked after a recent injury.
Mehmet Zeki Celik is likely to come in, whilst Andrea Belotti could replace Paulo Dybala in attack for the trip to Moldova.
Former Ukraine goalkeeper Maksym Koval is set to start for Sheriff, whilst they look to Cedric Badolo for pace and goals from the flank.
Sheriff predicted XI vs AS Roma (3-4-3): Koval; Zohouri, Garananga, Tovar, Artunduaga; Joao Paulo, Kiki, Ademo; Mbekeli, Luvannor, Badolo.
AS Roma predicted XI vs Sheriff (3-5-2): Rui Patricio; Mancini, Llorente, Ndicka; Celik, Aouar, Paredes, Bove, Zalewski; Belotti, Lukaku.
Sheriff vs AS Roma: When does the Europa League fixture start?
Kick-off in the Europa League Matchday 1 fixture of Sheriff vs AS Roma is set for 18:45 CEST, local time in Italy, on Thursday, September 20.
For viewers in the United Kingdom and Ireland, the game will start at 17:45 BST. That is 12:45 EDT / 09:45 PDT in the United States.
Sheriff vs AS Roma: Where to watch the Europa League fixture?
For fans in the United States, Sheriff vs AS Roma will be on Paramount+ along with other fixtures on Europa League Matchday 1.
Sheriff vs AS Roma will be shown on TNT Sports 5 in the United Kingdom and Ireland.